Variations in Gold Nanoparticle Size on DNA Damage: A Monte Carlo Study Based on a Multiple-Particle Model Using Electron Beams

Research is currently focused on maximizing cancer cell death while minimizing harm to healthy cells. Gold nanoparticles (GNPs) have been extensively studied as a radiosensitizer improve sparing normal tissue. Previous research and simulations demonstrated that the presence of single GNP increases DNA damage dose. In this study, Monte Carlo simulation using Geant4-DNA code was used investigate effects multiple GNPs when exposed electron beams with energies 50, 100, 150, 200 keV. The study examined caused by 1–4 same total volume analyzing both single- double-strand breaks. results indicate increasing number decreasing beam energy strand Although increased, proportion breaks remained unchanged in relation